Bioprinting Solutions

Bioprinting Solutions

The solution applies microelectronics, microfluidics, and MEMS technologies to a variety of applications in biological systems, including 3D bioprinting, point-of-care diagnostics, sequencing, drug delivery, and microfluidic biomedical research. Our biosynthetic printing technology has obtained the microfluidic technology licensed by many domestic biological companies and national key experimental units. These technologies have a research and development history of 20 years.

Process field

  • Cell/Gene/Protein Synthesis
  • Biological tissue and organ printing
  • drug delivery
  • Disease screening and point-of-care diagnosis
  • Microfluidics and Organ Chips for Biomedical R&D

Cells, as the basic unit of biological structure and function, study their related biological behaviors and their laws and essences, which is of great significance for exploring the mechanism and treatment of diseases. The study of cells is a complex project. Cells are in a complex microenvironment in the human body, and the cells are small in size and diverse in type. Cell identification, metabolite detection, internal component analysis, cell structure and function are carried out at the cellular level. Characterization, cell-to-cell interaction analysis and other tasks are also very difficult. Because of the small sample size, low analyte concentration and complex sample system, cell-level analysis is a huge challenge to traditional research and analysis methods and techniques. The method of dielectrophoresis (DEP) in a non-uniform electric field can effectively carry out non-contact processing of single cells. The microwaves are formed by drilling holes in a flexible printed circuit board covered with three metal layers, so that each microwave forms three ring electrodes. An implementation of polystyrene beads and batteries including a set of microwave tubes and a fluidic device for filling the microwave tubes with saline buffer from the bottom and dispensing the particles into the microwave tubes from the top. Active microwaves are expected to replace single-flow chambers or channel chips, with the main advantages of separating cells at different locations, enabling flexible supernatant replacement, simplifying single-cell recovery procedures, and ensuring mechanical compatibility with standard high-density microtiter plates However, there are still high-throughput pain points to be solved. In this technique, polystyrene beads and cells are uniformly distributed using MicroFab's Jet Drive III and anMJ-A, ejecting droplets with a volume of 0.5 nl. In the experiment, the dilution parameter was 105 cells/ml. By analyzing the statistical distribution of cells per drop, it was found that when 10 cells were dropped in each microwell, an average of 0.5 cells was expected, which could effectively obtain a single cell.

Application scenarios